Amides

Today organolithium amides are indispensable tools in modern, selective organic synthesis.

These bases are typically used for the formation of enolates. Another important application is the ortho-selective deprotonation of aromatic substrates.

Albemarle offers a great variety of different amides. These reagents include amides such as LiNH2, lithium diisopropylamide (LDA), lithium hexamethyldisilazide (LHMDS, LHS), and magnesium bis (diisopropyl)amide (MDA).

Lithium Amides

Albemarle provides lithium amides starting with lithium amide (LiNH2) up to hindered amides such as lithium diisopropylamides (LDA), and lithium hexamethyldisilazide (LHMDS, LHS).

Organolithium amides are indispensable tools in modern, selective organic synthesis. These bases are typically used for the formation of enolates. Another important application is the ortho-selective deprotonation of aromatic substrates.

Magnesium Amides (MDA)

Albemarle also provides magnesium amides starting with magnesium bis(diisopropyl)amide (MDA) up to Knochel Hauser bases.

Organomagnesium amides are indispensable tools in modern, selective organic synthesis. Magnesium-di(amides) offer through the modified base potential ways to control a synthetic reaction.

In general, magnesium-diamides have lower reactivity; this makes them thus more stable against solvents such as ethers, especially THF.

These bases are typically used for the formation of enolates. Another important application is the ortho-selective deprotonation of aromatic substrates.